KF/Al2O3 Promoted Aza-Michael Addition of 4-Aryl-7,7-Dimethyloctahydro-Quinazolinones to α, β-Ethylenic Compounds
نویسندگان
چکیده
منابع مشابه
Michael addition of Pyrrole and indole to α,β- unsaturated compounds in the Presence of oxalic acid
A Simple and efficient method for Michael addition of pyrrole and indole to α,β- un saturated compounds has been developed in the presence of oxalic acid under refluxing reaction condition was achieved.
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A synthetic approach for the preparation of a new class of highly conjugated unnatural α-amino acids bearing a 5-arylpyrazole side-chain has been developed. Horner-Wadsworth-Emmons reaction of an aspartic acid derived β-keto phosphonate ester with a range of aromatic aldehydes gave β-aryl α,β-unsaturated ketones. Treatment of these with phenyl hydrazine followed by oxidation allowed the regiose...
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The 1,4-addition of a monofluoromethyl nucleophile to a variety of alpha,beta-unsaturated compounds has been achieved under mild conditions using either phosphines or potassium carbonate at room temperature. alpha-Substituted fluoro(phenylsulfonyl)methane easily undergoes Michael addition to alpha,beta-unsaturated ketones, esters, nitriles, sulfones, as well as propynoates at room temperature t...
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A highly enantio- and diastereoselective sulfa-Michael addition of thioacetic acid to α,β-disubstituted nitroalkenes catalysed by a chiral squaramide organocatalyst has been described. This organocatalytic reaction at an extremely low catalyst loading (0.2 mol%) furnished synthetically useful β-nitro sulfides in excellent yields with good diastereoselectivities and high enantioselectivities (up...
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ژورنال
عنوان ژورنال: Journal of Chemical Research
سال: 2011
ISSN: 1747-5198,2047-6507
DOI: 10.3184/174751911x13129294387591